Remodeling of myocardial energy and metabolic homeostasis in a sheep model of persistent atrial fibrillation

Atrial fibrillation (AF) is the most common progressive cardiac arrhythmia and is often associated with rapid contraction in both atria and ventricles. The role of atrial energy and metabolic homeostasis in AF progression is under-investigated.To determine the remodeling of energy metabolism during persistent AF and the effect of eplerenone (EPL), an aldosterone inhibitor, on metabolic homeostasis.A nonsustained atrial pacing sheep model was...