Review paper
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Abstract
In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good...
Paper Details
Title
T Cell Dysfunction in Cancer Immunity and Immunotherapy
Published Date
Jul 19, 2019
Journal
Volume
10
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Notes
History