Review paper
Beta-Cell Dedifferentiation in Type 2 Diabetes: Concise Review
Abstract
Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-cell failure, which is manifested under cellular stress induced by metabolic overload. The decrease in the functional β-cell mass associated with T2D has been attributed primarily to β-cell death; however, studies in recent years suggested that β-cell dedifferentiation may contribute to this decline. The mechanisms linking genetic factors and cellular stress to...
Paper Details
Title
Beta-Cell Dedifferentiation in Type 2 Diabetes: Concise Review
Published Date
Jul 31, 2019
Journal
Volume
37
Issue
10
Pages
1267 - 1272
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