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Stem Cells
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#1Anna Salerno (University of Liverpool)H-Index: 14
#2Kyla Brady (University of Liverpool)H-Index: 5
Last. Anthony P. Hollander (University of Liverpool)H-Index: 4
view all 9 authors...
Mesenchymal stem cells (MSCs) have been investigated as a potential injectable therapy for the treatment of knee osteoarthritis, with some evidence of success in preliminary human trials. However, optimisation and scale-up of this therapeutic approach depends on the identification of functional markers that are linked to their mechanism of action. One possible mechanism is through their chondrogenic differentiation and direct role in neo-cartilage synthesis. Alternatively, they could remain undi...
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#1Artur Cieslar-Pobuda (Oslo University Hospital)H-Index: 5
#2Theresa D. Ahrens (Oslo University Hospital)
Last. Judith Staerk (Oslo University Hospital)H-Index: 18
view all 6 authors...
Embryonic stem cell (ESC) renewal and differentiation is regulated by metabolites that serve as co-factors for epigenetic enzymes. Increase of α-ketoglutarate (α-KG), a co-factor for histone and DNA demethylases, triggers multi-lineage differentiation in human ESCs. To gain further insight how the metabolic fluxes in pluripotent stem cells can be influenced by inactivating mutations in epigenetic enzymes, we generated human ESCs deficient for de novo DNA methyltransferases (DNMT) 3A and 3B. Our ...
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#1Megan Fitzgerald (UPenn: University of Pennsylvania)
#2Nathaniel P. Sotuyo (UPenn: University of Pennsylvania)H-Index: 1
Last. Stewart A. Anderson (UPenn: University of Pennsylvania)H-Index: 48
view all 4 authors...
The cerebral cortex functions by the complex interactions of intrinsic and extrinsic neuronal activities, glial actions, and the effects of humoral factors. The intrinsic neuronal influences are mediated by two major subclasses, excitatory glutamatergic neurons that generally have axonal projections extending beyond the neuron's locality, and inhibitory GABAergic neurons that generally project locally. These interneurons can be grouped based on morphological, neurochemical, electrophysiological,...
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#1Junchao Liu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Peng Qiu (SJTU: Shanghai Jiao Tong University)
Last. Zhiyou Peng (SJTU: Shanghai Jiao Tong University)H-Index: 10
view all 11 authors...
Adipose-derived mesenchymal stem cells (ASCs) are multipotent stromal cells that possess considerable therapeutic potential for tissue remodeling. However, their protective mechanism in critical limb ischemia (CLI) has not been fully defined. After the occlusion of blood vessels, hypoxia becomes a prominent feature of the ischemic limb. This study investigated the immunomodulatory effect of ASCs on ischemic muscle repair and explored the specific mechanism. We found that the ability of RAW264.7 ...
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#1Jung Woo Park (UM: University of Macau)H-Index: 11
#2Siyi Fu (UM: University of Macau)
Last. Ren-He Xu (UM: University of Macau)H-Index: 29
view all 4 authors...
The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and other lineages are known to be controlled by various extrinsic and intrinsic signals. The dysregulation of the MSC differentiation balance has been linked to several pathophysiological conditions, including obesity and osteoporosis. Previous research of the molecular mechanisms governing MSC differentiation has mostly focused on transcriptional regulation. However, recent findings are revealing the underrated r...
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#1Oh-Joon Kwon (UW: University of Washington)H-Index: 2
#2Jong Min Choi (BCM: Baylor College of Medicine)
Last. Li Xin (UW: University of Washington)H-Index: 28
view all 9 authors...
The phenotypic and functional heterogeneity of the mouse prostate epithelial cell lineages remains incompletely characterized. We show that the Sca-1+ luminal cells at the mouse proximal prostate express Sox2. These cells are replicative quiescent, castration resistant, and do not possess secretory function. We use the Probasin-CreERT2 and Sox2-CreERT2 models in concert with a fluorescent reporter line to label the Sca-1- and Sca-1+ luminal cells, respectively. By a lineage tracing approach, we ...
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#1Romy Kronstein-Wiedemann (TUD: Dresden University of Technology)H-Index: 1
#2Paulina Nowakowska (German Red Cross)H-Index: 4
Last. Torsten Tonn (TUD: Dresden University of Technology)H-Index: 43
view all 8 authors...
The ABO blood group system is the most important factor in clinical transfusion medicine and is implicated in a number of human diseases. ABO antigens are not confined to red blood cells (RBCs) and are widely expressed in a variety of human cells and tissues. To date, many alleles with variant ABO expression have been identified and in many cases trace to one of the >250 reported genetic variations in the respective glycosyltransferase. The role of microRNAs (miRNAs) in the regulation of blood g...
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#1Aseel M. Sharaireh (MMU: Manchester Metropolitan University)
#2Lorna M. FitzPatrick (MMU: Manchester Metropolitan University)H-Index: 3
Last. Richard D. Unwin (University of Manchester)H-Index: 26
view all 5 authors...
Inhibition of E-cad in mouse embryonic stem cells (mESCs) leads to a switch from LIF-BMP to Activin/Nodal-dependent pluripotency, consistent with transition from a naive to primed pluripotent phenotype. We have used both genetic ablation and steric inhibition of E-cad function in mESCs to assess alterations to phenotype using quantitative mass spectrometry analysis, network models, and functional assays. Proteomic analyses revealed that one third of detected proteins were altered in E-cad null m...
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#1Sanja Bojic (University of Kragujevac)H-Index: 9
#2Matias M. FalcoH-Index: 2
Last. Roman Bauer (Newcastle University)H-Index: 9
view all 11 authors...
Increased pollution by plastics has become a serious global environmental problem, but the concerns for human health have been raised after reported presence of microplastics (MPs) and nanoplastics (NPs) in food and beverages. Unfortunately, few studies have investigate the potentially harmful effects of MPs/NPs on early human development and human health. Therefore, we used a new platform to study possible effects of polystyrene NPs (PSNPs) on the transcription profile of preimplantation human ...
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#1Hwan Hee Park (SNU: Seoul National University)H-Index: 2
#2Seung-Hee Lee (SNU: Seoul National University)H-Index: 39
Last. Kyung-Sun Kang (SNU: Seoul National University)H-Index: 45
view all 8 authors...
Human mesenchymal stem cells (MSCs) are promising therapeutics for autoimmune diseases due to their immunomodulatory effects. In particular, human umbilical cord blood-derived MSCs (hUCB-MSCs) have a prominent therapeutic effect on atopic dermatitis (AD). However, the underlying mechanism is unclear. This study investigated the role of transforming growth factor-beta (TGF-beta) in the therapeutic effect of hUCB-MSCs on AD. Small interfering RNA (siRNA)-mediated depletion of TGF-beta disrupted th...
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Top fields of study
Molecular biology
Progenitor cell
Stem cell
Biology
Cell biology