Original paper
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
Abstract
Brain tumor stem cells (BTSCs) are a chemoresistant population that can drive tumor growth and relapse, but the lack of BTSC-specific markers prevents selective targeting that spares resident stem cells. Through a ribosome-profiling analysis of mouse neural stem cells (NSCs) and BTSCs, we find glycerol-3-phosphate dehydrogenase 1 (GPD1) expression specifically in BTSCs and not in NSCs. GPD1 expression is present in the dormant BTSC population,...
Paper Details
Title
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
Published Date
Aug 1, 2019
Journal
Volume
25
Issue
2
Pages
241 - 257.e8
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Notes
History