Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin‐induced apoptosis through impaired autophagy and mitochondrial dysfunction

Rapamycin is well‐recognized in the clinical therapeutic intervention for patients with cancer by specifically targeting mammalian target of rapamycin (mTOR) kinase. Rapamycin regulates general autophagy to clear damaged cells. Previously, we identified increased expression of messenger RNA levels of NBR1 (the neighbor of BRCA1 gene; autophagy cargo receptor) in human urothelial cancer (URCa) cells, which were not exhibited in response to...