Original paper
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Abstract
Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet studies in aged-frail adults and old mice demonstrated that their platelets are hyperreactive and form larger thrombi. We identified tumor necrosis...
Paper Details
Title
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Published Date
Aug 29, 2019
Journal
Volume
134
Issue
9
Pages
727 - 740
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Notes
History