Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Abstract
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. While RIG-I and...
Paper Details
Title
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Published Date
Jul 17, 2019
Journal
Volume
10
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