Lymphatic clearance is the main drainage route of lamotrigine-loaded micelles following delivery to the brain

Objectives This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin-6 (IL-6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics. Methods The drug concentrations in the deep cervical lymph node, superficial cervical lymph...