Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer
Abstract
MALT1 is a key mediator of NF-κB signaling and a main driver of B-cell lymphomas. Remarkably, MALT1 is expressed in the majority of pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine pancreatic tissue. Following, MALT1 shows off to be a specific target in cancer cells of PDAC without affecting regular pancreatic cells. Therefore, we studied the impact of pharmacological MALT1 inhibition in pancreatic cancer and...
Paper Details
Title
Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer
Published Date
Jul 25, 2019
Volume
146
Issue
6
Pages
1618 - 1630
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