International Journal of Cancer
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#1Jia‐Bao He (Southern Medical University)
#1He Jia‐Bao (Southern Medical University)
Last. Qi‐Fa Liu (Southern Medical University)
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Central nervous system leukemia (CNSL) relapse is relatively common among Philadelphia chromosome positive (Ph+) leukemia patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT). The prognosis of patients is dismal for those with a BCR-ABL T315I mutation, which is resistant to TKIs including second-generation drugs. We assessed ponatinib for nine patients with recurrent Ph+ CNSL and a T315I mutation after allo-HSCT, including five patients with Ph+ acute lymphoblastic...
#1Emilie Moati (Paris V: Paris Descartes University)H-Index: 2
#2Hélène Blons (Paris V: Paris Descartes University)H-Index: 39
Last. Aziz Zaanan (Paris V: Paris Descartes University)H-Index: 13
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: In metastatic colorectal cancer (mCRC), circulating tumor DNA (ctDNA) monitoring can be used to genotype tumors and track clonal evolution. We investigated the clearance of RAS mutated clones under chemotherapy pressure by ctDNA analysis in patients with a RAS mutated mCRC. Patients with a RAS mutated tumor included in the prospective PLACOL study were monitored for ctDNA. Analyses were based on optimized targeted next-generation sequencing and/or droplet-based digital polymerase chain reactio...
2 CitationsSource
#1Teresa de Rojas (European Organisation for Research and Treatment of Cancer)H-Index: 3
#2Bernd Kasper (Heidelberg University)H-Index: 20
Last. Martin G. McCabe (University of Manchester)H-Index: 17
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: For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. EORTC-SPECTA, an academic translational research infrastructure for biomaterial collection, will explicitly recruit AYA patients and will therefore collect empirical data to bridge the molecular gap between pediatric and adult oncology. The initial pilot study, activated in February 2019 across Europe, will recruit 100 AYA patients (aged 12-29 years) with newly diagnosed or relapsed high-g...
1 CitationsSource
#1Frederique J. Vink (VU: VU University Amsterdam)H-Index: 1
#2Christophorus Joannes Lambertus Maria Meijer (VU: VU University Amsterdam)H-Index: 131
Last. Daniëlle A.M. Heideman (VU: VU University Amsterdam)H-Index: 45
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Widespread adoption of primary human papillomavirus (HPV)-based screening has encouraged the search for a triage test which retains high sensitivity for the detection of cervical cancer and precancer, but increases specificity to avoid overtreatment. Methylation analysis of FAM19A4 and miR124-2 genes has shown promise for the triage of high-risk (hr) HPV-positive women. In this study, we assessed the consistency of FAM19A4/miR124-2 methylation analysis in the detection of cervical cancer in a se...
4 CitationsSource
#1Nicole Grau (KIT: Karlsruhe Institute of Technology)H-Index: 3
#2Sandra D. Scherer (KIT: Karlsruhe Institute of Technology)H-Index: 2
Last. Jonathan P. Sleeman (KIT: Karlsruhe Institute of Technology)H-Index: 47
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: Metastasis is a multistep process, during which circulating tumor cells traffic through diverse anatomical locations. Stable inducible marking of tumor cells in a manner that is tightly spatially and temporally controlled would allow tracking the contribution of cells passing through specific locations to metastatic dissemination. For example, tumor cells enter the lymphatic system and can form metastases in regional lymph nodes, but the relative contribution of tumor cells that traffic throug...
#1Christopher L Heidler (Heidelberg University)H-Index: 1
#2Eva K Roth (Heidelberg University)H-Index: 2
Last. Andreas E. Kulozik (Heidelberg University)H-Index: 61
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Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to study promising novel agents for the treatment of pediatric osteosarcoma. The checkpoint kinase (chk) inhibitor prexasertib (LY2606368) and its salt form (LSN2940930) have recently been shown to be active in adult and pediatric malignancies, including sarc...
1 CitationsSource
#1David VeyerH-Index: 3
#2Maxime Wack (Paris V: Paris Descartes University)H-Index: 2
Last. Hélène Péré (Paris V: Paris Descartes University)H-Index: 11
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We aimed to determine whether pre-therapeutic assessment of HPV circulating tumoral DNA (HPV ctDNA) by droplet-based digital PCR (ddPCR) could constitute a predictive and prognostic biomarker for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). A mono-institutional prospective biomarker study on 66 patients with p16+/HPV16-positive oropharyngeal squamous cell carcinoma (OPSCC) was conducted in European Georges Pompidou Hospital, Paris, France. Blood samples were collected at the tim...
1 CitationsSource
#1Caroline Laheurte (French Institute of Health and Medical Research)H-Index: 7
Last. Olivier Adotevi (French Institute of Health and Medical Research)H-Index: 19
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Biochemical recurrence (BCR) occurs in up to 40% of prostate cancer patients after prostatectomy. In our study, we performed an immune monitoring study in 20 prostate cancer patients with BCR previously treated with metronomic cyclophosphamide (mCTX). We observed a decrease of regulatory T cells (Tregs) from 2 months and this was more pronounced after 6 months of mCTX treatment. This drop of Tregs was associated with increased level of activated HLADR+ CD45R0+ T cells in peripheral blood. Furthe...
#1Yan Wu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Yu Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Maigeng Zhou (CCDC: Chinese Center for Disease Control and Prevention)H-Index: 42
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: Melanoma is an aggressive form of skin cancer, and a worldwide problem with increasing incidence. Little is known about the burden of melanoma in the Chinese population. We evaluated temporal trends and geographic variation in melanoma-associated burden, to narrow an important knowledge gap concerning the consequences of this disorder across time, provinces in China. After the general analytic strategy used in the 2017 Global Burden of Disease study, we analyzed the incidence, mortality, preva...
1 CitationsSource
#1Tyler B. Kratzer (UM: University of Michigan)
Last. Alison M. Mondul (UM: University of Michigan)H-Index: 36
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: Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included women and nonsmokers. We conducted a nested case-control study in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). Cases (n = 323) were matched 1:1 to cont...
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Cancer research