Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development
Abstract
During development, ribosome biogenesis and translation reach peak activities, due to impetuous cell proliferation. Current models predict that protein synthesis elevation is controlled by transcription factors and signalling pathways. Developmental models addressing translation factors overexpression effects are lacking. Eukaryotic Initiation Factor 6 (eIF6) is necessary for ribosome biogenesis and efficient translation. eIF6 is a single gene,...
Paper Details
Title
Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development
Published Date
Nov 1, 2019
Journal
Volume
455
Issue
1
Pages
100 - 111
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