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Developmental Biology
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#1Yuta Takase (Kyoto University)H-Index: 3
#2Yoshiko Takahashi (Kyoto University)H-Index: 30
Abstract We describe a method by which early developing vasculature can be gene-manipulated independently of the heart in a spatio-temporally controlled manner. Lipofectamine 2000 or 3000, an easy-to-use lipid reagent, has been found to yield a high efficiency of transfection when co-injected with GFP DNA within a critical range of lipid concentration. By exploiting developmentally changing patterns of vasculature and blood flow, we have succeed in controlling the site of transfection: injection...
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#1Indira Paddibhatla (University of Hyderabad)H-Index: 2
#2Dushyant Kumar Gautam (University of Hyderabad)H-Index: 1
Last.Rakesh K. Mishra (Council for Scientific and Industrial Research)H-Index: 28
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Abstract Proper genetic and epigenetic regulation is necessary to maintain the identity and integrity of cells. Enzymes involved in post-transcriptional modifications of histones are key factors in epigenetic mechanisms. Such modifications are also gaining importance for their role in growth and development of cancer. SETDB1 catalyzes the epigenetic mark of lysine-9 methylation of histone-3. In this study, we explored the role of SETDB1 in Drosophila hematopoiesis. We show that SETDB1 controls t...
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#1Katherine Harding (Harvard University)H-Index: 1
#2Kristin White (Harvard University)H-Index: 25
Abstract Cell proliferation and cell death are opposing but fundamental aspects of development that must be tightly controlled to ensure proper tissue organization and organismal health. Developmental apoptosis of abdominal neuroblasts in the Drosophila ventral nerve cord is controlled by multiple upstream spatial and temporal signals, which have also been implicated in control of cell proliferation. It has therefore remained unclear whether developmental apoptosis is linked to active cell proli...
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#1Anna R. Duncan (Yale University)H-Index: 2
#2Delfina P. González (Yale University)
Last.John N. Griffin (Yale University)H-Index: 5
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Abstract Congenital heart disease (CHD) is a major cause of morbidity in the pediatric population yet its genetic and molecular causes remain poorly defined. Previously, we identified AGMO as a candidate heterotaxy disease gene, a disorder of left-right (LR) patterning that can have a profound effect on cardiac function. AGMO is the only known alkylglycerol monooxygenase, an orphan tetrahydrobiopterin dependent enzyme that cleaves the ether linkage in alkylglycerols. However, whether AGMO plays ...
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#1Yoshio Wakamatsu (Tohoku University)H-Index: 14
#2Kunihiro Suzuki (Nihon University)H-Index: 4
Abstract Neonates of marsupial mammals are altricial at birth, because their gestation period is relatively short compared to placental mammals. Yet, as they need to travel to the teat from the birth canal, and suckle on the mother’s milk, forelimbs and jaws develop significantly early. Previous studies in opossum (Monodelphis domestica), an experimental marsupial model, have revealed that cranial neural crest cells are generated significantly early compared to those in placental mammals, such a...
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#1Jianlong Li (Clarkson University)H-Index: 1
#2Margaret R. Dedloff (Clarkson University)
Last.Kenneth N. Wallace (Clarkson University)H-Index: 13
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Abstract The intestinal epithelium has constant turnover throughout the life of the organ, with apoptosis of cells at the tips of folds or villi releasing cells into the lumen. Due to constant turnover, epithelial cells need to be constantly replaced. Epithelial cells are supplied by stem cell niches that form at the base of the interfold space (zebrafish) and crypts (birds and mammals). Within the adult stem cell niche of mammals, secretory cells such as Paneth and goblet cells play a role in m...
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#1Huayang Zhang (Ha Tai: Xiamen University)H-Index: 1
#2Shuang Chen (Ha Tai: Xiamen University)
Last.Guang Li (Ha Tai: Xiamen University)H-Index: 9
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Abstract The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organizer. The present results show that Lefty overexpression abolishes the organizer; the embryos were severely ventralized and posteriorized, and failed to develop anterior and d...
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#1Marleen Klann (Whitney Laboratory for Marine Bioscience)
#2Elaine C. Seaver (Whitney Laboratory for Marine Bioscience)H-Index: 28
Abstract The transcription factor Pax6 is an important regulator of early animal development. Loss of function mutations of pax6 in a range of animals result in a reduction or complete loss of the eye, a reduction of a subset of neurons, and defects in axon growth. There are no studies focusing on the role of pax6 during development of any lophotrochozoan representative, however, expression of pax6 in the developing eye and nervous system in a number of species suggest that pax6 plays a highly c...
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#1Joana M. D. Portela (UvA: University of Amsterdam)
#2Callista L. Mulder (UvA: University of Amsterdam)H-Index: 4
Last.Ans M. M. van Pelt (UvA: University of Amsterdam)H-Index: 30
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Abstract The current strategy to preserve fertility of male prepubertal cancer patients consists of cryopreservation of a testicular tissue biopsy containing spermatogonial stem cells (SSCs). While in humans, fertility restoration strategies from prepubertal testicular tissues are still under investigation and have not yet resulted in complete germ cell differentiation, in mice various studies have described production of sperm and offspring through testicular organ culture and transplantation o...
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#1Yuya OkuzakiH-Index: 2
#2Hidenori KaneokaH-Index: 4
Last.Ken-ichi NishijimaH-Index: 15
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Abstract The differentiation of primordial germ cells (PGCs) is a fundamental step in development. PR domain-containing protein 14 (PRDM14) and B lymphocyte-induced maturation protein 1 (BLIMP1) play pivotal roles in mouse PGC specification. In the present study, we assessed the roles of chicken orthologs of PRDM14 and BLIMP1 in PGC development. PRDM14 and BLIMP1 were expressed in blastodermal cells and PGCs. The in vivo knockdown of PRDM14 or BLIMP1 by introducing a replication-competent retrov...
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