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#1Qinggang Li (Chinese PLA General Hospital)H-Index: 8
#2Jia-yao Ji (Chinese PLA General Hospital)H-Index: 2
Last. Guanyan Cai (Chinese PLA General Hospital)
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Abstract Congenital anomalies of the urinary tract are a significant cause of morbidity in infancy, and many congenital anomalies are linked to ureter development; however, the mechanism by which congenital anomalies control ureter development remains unknown. The loss of Robo2 can cause ureter defects and vesicoureteral reflux. However, how Robo2 impacts ureter development is unclear. We found that ROBO2 is expressed in the common nephric duct (CND) and primitive bladder, and impacts CND migrat...
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#1Moe TakahashiH-Index: 1
Last. Taneaki NakagawaH-Index: 23
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Abstract Tissue macrophages, which are ubiquitously present innate immune cells, play versatile roles in development and organogenesis. During development, macrophages prune transient or unnecessary synapses in neuronal development, and prune blood vessels in vascular development, facilitating appropriate tissue remodeling. In the present study, we identified that macrophages contributed to the development of pupillary morphology. Csf1op/op mutant mice, in which ocular macrophages are nearly abs...
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#1Tiffany T. Terry (UVA: University of Virginia)
#2Tao Cheng (WashU: Washington University in St. Louis)H-Index: 5
Last. Hui Zong (UVA: University of Virginia)
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Abstract During cerebellar development, granule cell progenitors (GCPs) proliferate exponentially for a fixed period, promoted by paracrine mitogenic factor Sonic Hedgehog (Shh) secreted from Purkinje cells (PCs). Dysregulation of Shh signaling leads to uncontrolled GCP proliferation and medulloblastoma. Serendipitously our previous work discovered insulin-like growth factor 1 (IGF1) as another key driver for medulloblastoma, which led to the current investigation into the role of IGF1 in GCPs d...
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#1Anna Babushkina (Rice University)
#2Peter Y. Lwigale (Rice University)H-Index: 13
Abstract During ocular development, periocular neural crest cells (pNC) migrate into the region between the lens and presumptive corneal epithelium to form the corneal endothelium and stromal keratocytes. Although defects in neural crest cell development are associated with ocular dysgenesis, very little is known about the molecular mechanisms involved in this process. This study focuses on the corneal endothelium, a monolayer of specialized cells that are essential for maintaining normal hydrat...
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#1Michelle Y. Hamline (UMN: University of Minnesota)H-Index: 3
#2Connie M. Corcoran (UMN: University of Minnesota)H-Index: 7
Last. Vivian J. Bardwell (UMN: University of Minnesota)H-Index: 36
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Abstract BCOR is a critical regulator of human development. Heterozygous mutations of BCOR in females cause the X-linked developmental disorder Oculofaciocardiodental syndrome (OFCD), and hemizygous mutations of BCOR in males cause gestational lethality. BCOR associates with Polycomb group proteins to form one subfamily of the diverse Polycomb repressive complex 1 (PRC1) complexes, designated PRC1.1. Currently there is limited understanding of differing developmental roles of the various PRC1 co...
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#1Ilham J.J. Alshami (University of Exeter)
#2Yosuke Ono (University of Exeter)H-Index: 9
Last. Tetsuhiro Kudoh (University of Exeter)H-Index: 19
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Abstract South American Gymnotiform knifefish possess electric organs that generate electric fields for electro-location and electro-communication. Electric organs in fish can be derived from either myogenic cells (myogenic electric organ/mEO) or neurogenic cells (neurogenic electric organ/nEO). To date, the embryonic development of EOs has remained obscure. Here we characterize the development of the mEO in the Gymnotiform bluntnose knifefish, Brachyhypopomus gauderio. We find that EO primordia...
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#1Florence D.M. Wavreil (Brown University)
#2Mamiko Yajima (Brown University)H-Index: 13
Abstract Asymmetric cell division (ACD) is a cellular process that forms two different cell types through a cell division and is thus critical for the development of all multicellular organisms. Not all but many of the ACD processes are mediated by proper orientation of the mitotic spindle, which segregates the fate determinants asymmetrically into daughter cells. In many cell types, the evolutionarily conserved protein complex of Gαi/AGS-family protein/NuMA-like protein appears to play critical...
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#1Matthew Shorey (PSU: Pennsylvania State University)H-Index: 3
#2Michelle C. Stone (PSU: Pennsylvania State University)H-Index: 11
Last. Melissa M. Rolls (PSU: Pennsylvania State University)H-Index: 28
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Abstract Neurons extend dendrites and axons to receive and send signals. If either type of process is removed, the cell cannot function. Rather than undergoing cell death, some neurons can regrow axons and dendrites. Axon and dendrite regeneration have been examined separately and require sensing the injury and reinitiating the correct growth program. Whether neurons in vivo can sense and respond to simultaneous axon and dendrite injury with polarized regeneration has not been explored. To inves...
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#1Haewon Jeon (Gyeongsang National University)H-Index: 1
#2Sujeong Gim (Gyeongsang National University)
Last. Chong Pyo Choe (Gyeongsang National University)H-Index: 2
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Abstract While pair-rule patterning has been observed in most insects examined, the orthologs of Drosophila pair-rule genes have shown divergent roles in insect segmentation. In the beetle Tribolium castaneum, while odd-skipped (Tc-odd) was expressed as a series of pair-rule stripes, RNAi-mediated knockdown of Tc-odd (Tc-oddRNAi) resulted in severely truncated, almost asegmental phenotypes rather than the classical pair-rule phenotypes observed in germbands and larval cuticles. However, consider...
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#1Heather Ray (UAB: University of Alabama at Birmingham)H-Index: 3
#2Chenbei Chang (UAB: University of Alabama at Birmingham)H-Index: 25
Abstract The transcription factor Hypermethylated in Cancer 1 (HIC1) is associated with both tumorigenesis and the complex human developmental disorder Miller-Dieker Syndrome. While many studies have characterized HIC1 as a tumor suppressor, HIC1 function in development is less understood. Loss-of-function mouse alleles show embryonic lethality accompanied with developmental defects, including craniofacial abnormalities that are reminiscent of human Miller-Dieker Syndrome patients. However, the ...
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