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Developmental Biology
IF
2.94
Papers
20800
Papers 20831
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Published on Jul 1, 2019in Developmental Biology2.94
Yuya Okuzaki1
Estimated H-index: 1
,
Hidenori Kaneoka4
Estimated H-index: 4
+ 7 AuthorsKen-ichi Nishijima15
Estimated H-index: 15
Abstract The differentiation of primordial germ cells (PGCs) is a fundamental step in development. PR domain-containing protein 14 (PRDM14) and B lymphocyte-induced maturation protein 1 (BLIMP1) play pivotal roles in mouse PGC specification. In the present study, we assessed the roles of chicken orthologs of PRDM14 and BLIMP1 in PGC development. PRDM14 and BLIMP1 were expressed in blastodermal cells and PGCs. The in vivo knockdown of PRDM14 or BLIMP1 by introducing a replication-competent retrov...
Published on Jun 1, 2019in Developmental Biology2.94
C. Tang1
Estimated H-index: 1
(Radboud University Nijmegen),
Renske J.E. van den Bijgaart1
Estimated H-index: 1
(Radboud University Nijmegen)
+ 6 AuthorsGosse J. Adema73
Estimated H-index: 73
(Radboud University Nijmegen)
Abstract Mammary glands are unique organs in which major adaptive changes occur in morphogenesis and development after birth. Breast cancer is the most common cancer and a major cause of mortality in females worldwide. We have previously identified the loss of expression of the transcription regulator DC-SCRIPT ( Zfp366 ) as a prominent prognostic event in estrogen receptor positive breast cancer patients. DC-SCRIPT affects multiple transcriptional events in breast cancer cells, including estrog...
Published on Jul 1, 2019in Developmental Biology2.94
Rachel Mullen (University of Texas MD Anderson Cancer Center), Alejandra E. Ontiveros (BCM: Baylor College of Medicine)+ 1 AuthorsRichard R. Behringer97
Estimated H-index: 97
(BCM: Baylor College of Medicine)
Abstract Anti-Mullerian hormone (AMH) is a member of the Transforming Growth Factor-β family of secreted signaling proteins. AMH is expressed in Sertoli cells of the fetal and adult testes and granulosa cells of the postnatal ovary. AMH is required for the regression of the Mullerian ducts in mammalian fetuses during male differentiation. AMH signals through its Type II receptor, AMHR2. AMHR2 is expressed in mesenchyme adjacent to the Mullerian ducts, and in Sertoli, Leydig, and granulosa cells....
Published on Jun 1, 2019in Developmental Biology2.94
Baotong Xie6
Estimated H-index: 6
(OHSU: Oregon Health & Science University),
David B. Morton23
Estimated H-index: 23
(OHSU: Oregon Health & Science University),
Tiffany Cook26
Estimated H-index: 26
(WSU: Wayne State University)
Abstract The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby blocking Yki-dependent transcriptional control. In post-mitotic Drosophila photoreceptors, a bistable negative feedback loop forms between the Hippo-dependent kinase Warts/L...
Published on Jul 1, 2019in Developmental Biology2.94
Arianna Russo1
Estimated H-index: 1
,
Guido Gatti (University of Milan)+ 8 AuthorsStefano Biffo28
Estimated H-index: 28
(University of Milan)
Abstract During development, ribosome biogenesis and translation reach peak activities, due to impetuous cell proliferation. Current models predict that protein synthesis elevation is controlled by transcription factors and signalling pathways. Developmental models addressing translation factors overexpression effects are lacking. Eukaryotic Initiation Factor 6 (eIF6) is necessary for ribosome biogenesis and efficient translation. eIF6 is a single gene, conserved from yeasts to mammals, suggesti...
Published on Jul 1, 2019in Developmental Biology2.94
Wende Zhu , Erin K. Botticelli + 9 AuthorsRoy J. Soberman36
Estimated H-index: 36
(Harvard University)
Abstract The imprinted delta like 1 homolog ( DLK1 ) - thyroxine deiodinase type III ( DIO3 ) locus regulates development and growth. Its imprinting regulation involves two differentially methylated regions (DMRs), intergenic-DMR (IG-DMR) and maternally expressed gene 3-DMR (Meg3-DMR). In mice, a maternal deletion of the IG-DMR leads to LOI in the locus, proving that the IG-DMR is a cis-acting imprinting control region of the locus. However, the Meg3-DMR overlaps with the promoter, exon 1 and in...
Published on Jul 1, 2019in Developmental Biology2.94
Pia C. Svendsen1
Estimated H-index: 1
(Alberta Children's Hospital),
Lindsay A. Phillips (Alberta Children's Hospital)+ 3 AuthorsWilliam J. Brook2
Estimated H-index: 2
(Alberta Children's Hospital)
Abstract mid and H15 encode Tbx20 transcription factors that specify ventral pattern in the Drosophila leg. We find that there are at least two pathways for mid and H15 specification of ventral fate. In the first pathway, mid and H15 negatively regulate Dpp, the dorsal signal in leg development. mid and H15 block the dorsalizing effects of Dpp signaling in the ventral leg. In loss- and gain-of-function experiments in imaginal discs, we show that mid and H15 block the accumulation of phospho-Mad,...
Published on Jul 1, 2019in Developmental Biology2.94
Xianghu Qu3
Estimated H-index: 3
(Vandy: Vanderbilt University),
Kate Violette1
Estimated H-index: 1
(Vandy: Vanderbilt University)
+ 5 AuthorsH Scottbaldwin36
Estimated H-index: 36
(Vandy: Vanderbilt University)
Abstract The mechanisms regulating endothelial cell response to hemodynamic forces required for heart valve development, especially valve remodeling, remain elusive. Tie1, an endothelial specific receptor tyrosine kinase, is up-regulated by oscillating shear stress and is required for lymphatic valve development. In this study, we demonstrate that valvular endothelial Tie1 is differentially expressed in a dynamic pattern predicted by disturbed flow during valve remodeling. Following valvular end...
Published on 2019in Developmental Biology2.94
Ashley W. Seifert14
Estimated H-index: 14
(UK: University of Kentucky),
Adam B. Cook1
Estimated H-index: 1
(UK: University of Kentucky),
Douglas Shaw (UK: University of Kentucky)
Abstract Salamanders are capable of full-thickness skin regeneration where removal of epidermis, dermis and hypodermis results in scar-free repair. What remains unclear is whether regeneration of these tissues recapitulates the cellular events of skin development or occurs through a process unique to regenerative healing. Unfortunately, information on the post-embryonic development of salamander skin is severely lacking, having focused on compartments or cell types, but never on the skin as a co...
Published on Jun 1, 2019in Developmental Biology2.94
Derek C Liberti (UPenn: University of Pennsylvania), Jarod A. Zepp3
Estimated H-index: 3
(UPenn: University of Pennsylvania)
+ 5 AuthorsEdward E. Morrisey63
Estimated H-index: 63
Abstract Lung endoderm development occurs through a series of finely coordinated transcriptional processes that are regulated by epigenetic mechanisms. However, the role of DNA methylation in regulating lung endoderm development remains poorly understood. We demonstrate that DNA methyltransferase 1 (Dnmt1) is required for early branching morphogenesis of the lungs and for restraining epithelial fate specification. Loss of Dnmt1 leads to an early branching defect, a loss of epithelial polarity an...
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