Original paper
The non-steroidal mineralocorticoid receptor antagonist finerenone prevents cardiac fibrotic remodeling
Abstract
Mineralocorticoid receptor (MR) overactivation promotes cardiac fibrosis. We studied the ability of the non-steroidal MR antagonist finerenone to prevent fibrotic remodeling. In neonatal rat cardiac fibroblasts, finerenone prevented aldosterone-induced nuclear MR translocation. Treatment with finerenone decreased the expression of connective tissue growth factor (CTGF) (74 ± 15% of control, p = 0.005) and prevented aldosterone-induced...
Paper Details
Title
The non-steroidal mineralocorticoid receptor antagonist finerenone prevents cardiac fibrotic remodeling
Published Date
Oct 1, 2019
Journal
Volume
168
Pages
173 - 183
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Notes
History