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Ulrich Laufs
Saarland University
462Publications
67H-index
21kCitations
Publications 459
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#1Yoon Ju Bae (Leipzig University)H-Index: 6
#2Jürgen Kratzsch (Leipzig University)H-Index: 61
Last.Ulrich LaufsH-Index: 67
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Abstract Marathon running is a physical and psychological stressor. We aimed to characterize the response of nine steroid hormones, which include estradiol, progesterone, testosterone, cortisol, aldosterone, 17-hydroxyprogesterone, cortisone, androstenedione, and dehydroepiandrosterone sulfate, to marathon running and their association with performance. Blood samples of sixty men (age: 49.3 ± 5.9 years) who participated in the Berlin marathon were collected within 3 days before, within 30 min an...
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#1Tanja B. Grammer (Heidelberg University)H-Index: 26
#2Alexander Dressel (Heidelberg University)H-Index: 6
Last.Winfried März (Medical University of Graz)H-Index: 90
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Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All r...
2 CitationsSource
#1Christian WernerH-Index: 20
#2Anne Hecksteden (Saarland University)H-Index: 12
Last.Ulrich LaufsH-Index: 67
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1 CitationsSource
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#1Daniel LavallH-Index: 7
#2Nadine Jacobs (Saarland University)H-Index: 1
Last.Ulrich LaufsH-Index: 67
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Abstract Mineralocorticoid receptor (MR) overactivation promotes cardiac fibrosis. We studied the ability of the non-steroidal MR antagonist finerenone to prevent fibrotic remodeling. In neonatal rat cardiac fibroblasts, finerenone prevented aldosterone-induced nuclear MR translocation. Treatment with finerenone decreased the expression of connective tissue growth factor (CTGF) (74 ± 15% of control, p = 0.005) and prevented aldosterone-induced upregulation of CTGF and lysyl oxidase (LOX) complet...
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#1Matthias Blüher (Leipzig University)H-Index: 79
#2Ulrich LaufsH-Index: 67
1 CitationsSource
#1Ulrich LaufsH-Index: 67
#2Ricardo Dent (Amgen)H-Index: 14
Last.M. John Chapman (NIH: National Institutes of Health)H-Index: 72
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1 CitationsSource
Eine chronische Inflammation im Rahmen von Autoimmunerkrankungen ist mit einer erhohten Rate an supraventrikularen und ventrikularen Arrhythmien vergesellschaftet, welche mit einer gesteigerten Morbiditat und Mortalitat assoziiert ist. Die Beteiligung des spezifischen Erregungsleitungssystems wird sehr haufig bei chronischen Autoimmunprozessen beobachtet, wenngleich die klinische Penetranz sehr unterschiedlich ist und therapiebedurftige Blockierungen nur selten auftreten. Fur die Pathogenese tac...
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Purpose of Review Low-density lipoprotein cholesterol (LDL-C) is one major cause of cardiovascular disease (CVD). In this review, we discuss current developments in the understanding of LDL-C as lifelong risk factor, treatment targets, and emerging approaches to reduce cardiovascular risk by lowering LDL-C.
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