Assessing Neuroprotective Agents for Aβ-Induced Neurotoxicity

A rise in amyloid-beta (Aβ) occurs years before pathology leading to Alzheimer’s disease (AD), indicating the presence of neuroprotective mechanisms in the brain. Multiple targets for Aβ have been identified in diverse contexts, including receptors linked to neuromodulation by physiological levels of Aβ. Signaling through Aβ-interacting receptors mediating neuromodulation may only partially overlap with signaling linked to neurotoxicity,...