Original paper
STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
Abstract
Cytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount type 1 interferon responses and succumb to...
Paper Details
Title
STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
Published Date
Jun 27, 2019
Journal
Volume
10
Issue
1
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Notes
History