Influence of Prediabetes on the Effects of Intensive Systolic Blood Pressure Control on Kidney Events

BACKGROUND More than one-third of US adults have prediabetes, which is typically accompanied by hypertension. METHODS We examined whether prediabetes modified the effects of intensive systolic blood pressure (SBP) lowering on the incidence of chronic kidney disease (CKD) and acute kidney injury (AKI) events in a post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). Diabetes was a SPRINT exclusion criterion. We defined...