Bilateral intermittent nasal obstruction in adolescent rats leads to the growth defects of mandibular condyle

This study aimed to evaluate the effects of nasal obstruction on mandibular growth, especially condyle, in adolescent rats and explore the possible mechanism with a focus on mesenchymal stem cells (MSCs) from condylar tissues.4-week-old male Sprague-Dawley rats were randomly divided into bilateral intermittent nasal obstruction (i.e. mouth-breathing, MB) and nasal-breathing (NB) groups. Self-made plugs were used to obstruct the nasal cavity in...