Blood pressure lowering medication initiation and fracture risk: a SWAN pharmacoepidemiology study

We examined the fracture risk after initiation of blood pressure–lowering drugs compared with initiation of antidepressants. Multivariable regression models demonstrated an increased risk of fracture among women initiating a blood pressure–lowering medication (HR 1.73, 95% CI 1.02–2.95). This is likely related to an increased risk of falls. Initiation of blood pressure–lowering drugs has been associated with fractures in several studies,...