Base pair editing in goat: nonsense codon introgression into FGF 5 results in longer hair
Abstract
The ability to alter single bases without homology directed repair (HDR) of double-strand breaks provides a potential solution for editing livestock genomes for economic traits, which are often multigenic. Progress toward multiplex editing in large animals has been hampered by the costly inefficiencies of HDR via microinjection of in vitro manipulated embryos. Here, we designed sgRNAs to induce nonsense codons (C-to-T transitions) at four target...
Paper Details
Title
Base pair editing in goat: nonsense codon introgression into FGF 5 results in longer hair
Published Date
Jul 23, 2019
Journal
Volume
286
Issue
23
Pages
4675 - 4692
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