Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation
Abstract
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were profiled by tandem-mass-tag-based proteomics at rest and at nine time points after infection; >8,000 host and 29 viral proteins were quantified, revealing mitochondrial remodeling and induction of one-carbon (1C)...
Paper Details
Title
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation
Published Date
Sep 1, 2019
Journal
Volume
30
Issue
3
Pages
539 - 555.e11
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