Optimization of menthol-loaded nanocapsules for skin application using the response surface methodology

Menthol is used as a natural coolant in numerous consumer healthcare products. However, low aqueous solubility and high volatility limit its applications. This study aimed to encapsulate menthol in lipid-core nanocapsules by using a nanoprecipitation method and to explore its skin application. Experiments were performed using a Box-Behnken design to investigate the influence of relevant causal parameters (weight proportions of menthol,...