Abstract 4967: Neoadjuvant chemotherapy promotes a transient increase of intratumoral T-cell density in colorectal liver metastases

Background: In metastatic colorectal cancer, only the microsatellite instable (MSI) subgroup of cases has so far demonstrated major responses to immune checkpoint inhibition. Increased infiltration of T lymphocytes in presumed non-responsive tumors has been shown to facilitate response to immune checkpoint inhibition. Cytotoxic chemotherapy might induce immunogenic cell death and cause infiltration of immune cells, turning “cold” tumors into...