Comparison of novel methods in two‐way enriched clinical trial design

Two‐way enriched design (TED) is a novel approach addressing placebo response in clinical trials. It is a two‐stage, randomized, placebo‐controlled trial design with enrichment in placebo non‐responders and treatment responders at the second stage. All data from the first stage and data from placebo non‐responders and treatment responders in the second stage are used for the final analysis of the treatment effect. The existing methods for the...