Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression

Objectives The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression. Methods The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life...