Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
Abstract
Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and...
Paper Details
Title
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability
Published Date
Apr 17, 2019
Journal
Volume
5
Issue
1
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