Original paper

High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Volume: 4, Issue: 1
Published: Jun 21, 2019
Abstract
Genomic screening of cancer patients for predisposing variants is traditionally based on age at onset, family history and type of cancer. Whereas the clinical guidelines have proven efficient in identifying families exhibiting classical attributes of hereditary cancer, the frequency of patients with alternative presentations is unclear. We identified and characterized germline variants in 636 patients with advanced solid cancer using whole exome...
Paper Details
Title
High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer
Published Date
Jun 21, 2019
Volume
4
Issue
1
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