Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding
Abstract
Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their interactions with tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the key processes of the Central Dogma of molecular biology emerged simultaneously and naturally from simple origins in a peptide•RNA partnership, eliminating the...
Paper Details
Title
Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding
Published Date
Oct 24, 2017
Volume
35
Issue
2
Pages
269 - 286
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