Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases

Aims In the search for blood‐based biomarkers of neurodegenerative diseases, we characterized the concentration of total prion protein (t‐PrP) in the plasma of neurodegenerative dementias. We aimed to assess its accuracy in this differential diagnostic context. Methods Plasma t‐PrP was measured in 520 individuals including healthy controls ( HC ) and patients diagnosed with neurological disease control ( ND ), Alzheimer's disease ( AD ),...