Whsc1 links pluripotency exit with mesendoderm specification
Abstract
How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in pluripotency exit and germ layer specification of embryonic stem cells. On induction of differentiation, a proportion of Whsc1-depleted embryonic stem cells remain entrapped in a pluripotent state and fail to form mesendoderm,...
Paper Details
Title
Whsc1 links pluripotency exit with mesendoderm specification
Published Date
Jun 24, 2019
Journal
Volume
21
Issue
7
Pages
824 - 834
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