Full-length de novo viral quasispecies assembly through variation graph construction
Abstract
Motivation Viruses populate their hosts as a viral quasispecies: a collection of genetically related mutant strains. Viral quasispecies assembly is the reconstruction of strain-specific haplotypes from read data, and predicting their relative abundances within the mix of strains is an important step for various treatment-related reasons. Reference genome independent (‘de novo’) approaches have yielded benefits over reference-guided approaches,...
Paper Details
Title
Full-length de novo viral quasispecies assembly through variation graph construction
Published Date
May 30, 2019
Journal
Volume
35
Issue
24
Pages
5086 - 5094
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Notes
History