DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas
Abstract
Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresentation in young patients, proclivity for the proximal colon and rarity of histologic dysplasia (referred to then as SSAs with dysplasia, SSADs). Once dysplasia develops, there is rapid progression to CRC, even at a small size. There is...
Paper Details
Title
DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas
Published Date
Jun 14, 2019
Journal
Volume
11
Issue
1
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