Impact of Cisplatin on the recent development of Pt coordination chemistry: a case study

An overview is presented on recent developments in selected areas of Pt coordination chemistry which were a direct consequence of the discovery of the antitumor activity of cis-Pt(NH3)2Cl2 (Cisplatin). These include complexes of PtII with oxygen donor atoms, mixed-valence state Pt compounds as well as diplatinum(III) complexes, and compounds containing nucleobases as well as a limited number of other heterocyclic ligands. Both the potential...