Metabolic adaptation is not observed after 8 weeks of overfeeding but energy expenditure variability is associated with weight recovery

A metabolic adaptation, defined as an increase in energy expenditure (EE) beyond what is expected with weight gain during overfeeding (OF), has been reported but also refuted. Much of the inconsistency stems from the difficulty in conducting large, well-controlled OF studies in humans.The primary aim of this study was to determine whether a metabolic adaptation to OF exists and if so, attenuates weight gain.Thirty-five young adults consumed 40%...