Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
Abstract
Under hypoxia, most of glucose is converted to secretory lactate, which leads to the overuse of glutamine-carbon. However, under such a condition how glutamine nitrogen is disposed to avoid over-accumulating ammonia remains to be determined. Here we identify a metabolic flux of glutamine to secretory dihydroorotate, which is indispensable to glutamine-carbon metabolism under hypoxia. We found that glutamine nitrogen is necessary to nucleotide...
Paper Details
Title
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
Published Date
Jan 14, 2019
Journal
Volume
10
Issue
1
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