Sepsis increases perioperative metastases in a murine model

Cancer surgery can promote tumour metastases and worsen prognosis, however, the effect of perioperative complications on metastatic disease remains unclear. In this study we sought to evaluate the effect of common perioperative complications including perioperative blood loss, hypothermia, and sepsis on tumour metastases in a murine model. Prior to surgery, pulmonary metastases were established by intravenous challenge of CT26LacZ colon cancer...