BMC Cancer
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#1Deke JiangH-Index: 9
#2Jia-En DengH-Index: 3
Last. S. Lilly ZhengH-Index: 47
view all 19 authors...
#1Xiaodong Li (NYU: New York University)
#2Katherine Sun (NYU: New York University)H-Index: 1
Last. Ruliang Xu (NYU: New York University)
view all 6 authors...
BACKGROUND: Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is more than 50% of the lesion. We aimed at assessing the gene expression profiles of the CRCs with any mucinous features (> 5%) in a retrospective study. METHODS: The data of a 50-gene next generation sequencing (NGS) panel of 166 CRCs was analyzed and the gene mutational profile w...
#1Zandra Engelbak Nielsen (Copenhagen University Hospital)
#2Stefan Eriksson (Uppsala University)H-Index: 24
Last. Tove Godskesen (Uppsala University)H-Index: 4
view all 7 authors...
BACKGROUND: Research and cancer care are closely intertwined; however, it is not clear whether physicians and nurses believe that clinical trials offer the best treatment for patients and, if so, whether this belief is justified. The aim of this study was therefore: (i) to explore how physicians and nurses perceive the benefits of clinical trial participation compared with standard care and (ii) whether it is justified to claim that clinical trial participation improves outcomes for cancer patie...
#1Patrick Berkovic (Katholieke Universiteit Leuven)
#2Akos Gulyban (ULB: Université libre de Bruxelles)
Last. L. JanvaryH-Index: 3
view all 12 authors...
BACKGROUND: Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife(R)) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). Additionally we wanted to evaluate influence of tumor, patient and treatment related parameters on local control (LC), lung and distant progression free- (lung PFS/Di-PFS) and overall survival (OS). METHODS: Consecutive patients with up to 5 ORLM (confirmed by FDG PET/CT) were included in this study. Inten...
#1H. Jonathan G. Lindström (LNU: Linnaeus University)
#2Ran Friedman (LNU: Linnaeus University)H-Index: 18
BACKGROUND: Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in other areas for preventing drug resistance. Two of these are (I) Axitinib, which inhibits the T315I mutation of BCR-ABL1, a main source of drug resistance, and (II) Asciminib, which has been developed as an allosteric BCR-ABL1 inhibitor, targeting an entirely different binding si...
#1Eric T. Miller (UCLA: University of California, Los Angeles)H-Index: 2
#2Sungyong You (Cedars-Sinai Medical Center)H-Index: 18
Last. Michael J. Quist (UCLA: University of California, Los Angeles)H-Index: 14
view all 15 authors...
BACKGROUND: Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previous studies have linked chromosomal instability (CIN), which generates aneuploidy following chromosomal missegregation during mitosis, to PC progression. Evidence of CIN includes broad copy number alterations (CNAs) spanning > 300 base pairs of DNA, which may also be measured via...
#1Arta Hoesseini (Erasmus University Medical Center)H-Index: 1
#2Emilie A. C. Dronkers (Erasmus University Medical Center)H-Index: 4
Last. Marinella P.J. Offerman (Erasmus University Medical Center)H-Index: 1
view all 6 authors...
BACKGROUND: Head and Neck cancer (HNC) is characterized by significant mortality and morbidity. Treatment is often invasive and interferes with vital functions, resulting in a delicate balance between survival benefit and deterioration in quality of life (QoL). Therefore, including prognostic information during patient counseling can be of great importance. The first aim of this study was to explore HNC patients' preferences for receiving prognostic information: both qualitative (general terms l...
#1Howard H. YangH-Index: 21
#2Hua Su (Leidos)
Last. Philip R. TaylorH-Index: 105
view all 9 authors...
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expression or influence survival at the genome-wide level in ESCC. METHODS: We performed miRNA and mRNA expression arrays in 113 ESCC cases with tumor/normal matched tissues to identify dysregulated miRNAs, to correlate miRNA and mRNA expressions, and to relate miRNA and mRNA expression...
#1Bi-Cheng Wang (HUST: Huazhong University of Science and Technology)
#2Bo-Ya Xiao ('SMMU': Second Military Medical University)
Last. Quentin Liu (SYSU: Sun Yat-sen University)H-Index: 21
view all 5 authors...
BACKGROUND: Induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) has been recommended as the first-line therapy for locoregional nasopharyngeal carcinoma (NPC). Due to the different chemotherapeutic drugs used in the IC and CCRT, the results remain controversial. METHODS: PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically retrieved to search potentially eligible clinical trials up to Sep 11, 2019. Eligible studies were registered and prosp...
#1Ditte Møller Ejegod (Copenhagen University Hospital)H-Index: 11
#2Camilla Lagheden (Karolinska University Hospital)
Last. Joakim Dillner (Karolinska University Hospital)H-Index: 75
view all 11 authors...
BACKGROUND: To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV assay with genotyping capabilities are becoming increasingly important in triage of HPV positive women in primary HPV screening. Here we evaluate a full genotyping HPV assay intended for primary screening. METHODS: The CLART(R) HPV4S (CLART4S) assay is a newly developed full-genot...
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