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BMC Cancer
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#1Xin Chen (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xiaoduan Li (SJTU: Shanghai Jiao Tong University)
Last.Xipeng Wang (SJTU: Shanghai Jiao Tong University)H-Index: 4
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Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) to the cytoplasm and consequently activates ras homolog (Rho) GTPases RhoA/Cdc42 activation to modulate the proliferation and migration abilities of EOC cells. We collect 94 ovarian cancer (OC) patients’ tissue samples to constitute tissue microarray (TMA) and analyze the MUC16 and p120ctn ...
#1C. D. Savci-Heijink (UvA: University of Amsterdam)H-Index: 1
#2H. Halfwerk (UvA: University of Amsterdam)H-Index: 1
Last.M. van Vliet (UvA: University of Amsterdam)H-Index: 67
view all 5 authors...
Background Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a subpopulation of patients that is more likely to develop visceral organ metastases will help elucidate mechanisms for the development of distant metastases and could be of clinical value. With this study we aimed to determine genomic predictors that would help to distinguish bre...
#1Jian Xu (Tianjin Medical University)
#2Gang Li (Tianjin Medical University)H-Index: 4
Last.Yuan Jie Niu (Tianjin Medical University)
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Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical trials hampered the attempt to establish a solid evidence base for its routine use. The purpose of this study was to evaluate the efficacy of the neoadjuvant chemotherapy combined with a ITP regimen including docetaxel, cisplatin and ifosfamide for treating advanced penile cancer patients....
#1A. Laprie (University of Toulouse)H-Index: 14
#2Soléakhéna Ken (University of Toulouse)
Last.Jonathan KhalifaH-Index: 5
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Background Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries a dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this is still low due to local relapses, mostly occurring in the irradiation field. As the ratio of spectra of choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging has been described as predictive for the site of local relapse, we hypothesized that dose escalation on these ...
#1Mian-Tao Wu (SYSU: Sun Yat-sen University)H-Index: 1
#2Su-Yin He (SYSU: Sun Yat-sen University)
Last.Hao Chen (SYSU: Sun Yat-sen University)H-Index: 8
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Despite recent advances in the treatments of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains controversial. The purpose of this study was to investigate the prognostic performance of pretreatment albumin to C-reactive protein ratio (ACR) in patients with HCC. This study included 409 initially diagnosed HCC patients retrospectively. The optimal cut-off points for distinguishing high and low ACR value was determined by the X-tile software. The chi-squared test was used for co...
#1Xiaoying Sun (SHU: Shanghai University)H-Index: 2
#2Raheleh Roudi (IUMS: Iran University of Medical Sciences)H-Index: 6
Last.Chengqian Yin (BU: Boston University)H-Index: 3
view all 10 authors...
Programmed cell death protein-1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have remarkable clinical efficacy in the treatment of non-small cell lung cancer (NSCLC); however, the breakdown of immune escape causes a variety of immune-related adverse events (irAEs). With the increasing use of PD-1/PD-L1 inhibitors alone or in combination with other therapies, awareness and management of irAEs have become more important. We aimed to assess the incidence and nature of irAEs associat...
#1Kai LiH-Index: 1
Last.Hexing Yuan (Soochow University (Taiwan))
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Background To evaluate the prognostic value of Lymphovascular Invasion (LVI) in patients with squamous cell carcinoma of the penis (SCCP) following surgery.
#1Yin-Hsun Feng (Chung Hwa University of Medical Technology)
#2Yu-Chu Su (NCKU: National Cheng Kung University)
Last.Ai-Li Shiau (NCKU: National Cheng Kung University)H-Index: 32
view all 9 authors...
Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermined, especially in regard to stem cell-related pathways. Egr1, osteopontin (OPN) and Oct4 expression in human lung cancer was determined by performing immunohistochemistry. Immunoblotting, ELISA, luciferase reporter assay, chromatin immunoprecipitation assay and RT-PCR were performed to valid...
#1Bo Li ('SMMU': Second Military Medical University)
#2Yan Wang ('SMMU': Second Military Medical University)H-Index: 6
Last.Jian Lu ('SMMU': Second Military Medical University)H-Index: 8
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Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and progression of colorectal carcinoma (CRC) is unclear. We evaluated the effect of corticosterone (CORT) on azoxymethane and dextran sulfate sodium (AOM/DSS)-induced carcinogenesis in the colorectum of C57BL/6 strain mice. Plasma level of CORT was detected by radioimmunoassay. The expression of ...
Last.Jun ChenH-Index: 2
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Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and progresses.
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