Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition
Abstract
MdfA is a prototypical H+-coupled multidrug transporter that is characterized by extraordinarily broad substrate specificity. The involvement of specific H-bonds in MdfA-drug interactions and the simplicity of altering the substrate specificity of MdfA contradict the promiscuous nature of multidrug recognition, presenting a baffling conundrum. Here we show the X-ray structures of MdfA variant I239T/G354E in complexes with three electrically...
Paper Details
Title
Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition
Published Date
Jun 17, 2019
Journal
Volume
2
Issue
1
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