Original paper
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Abstract
The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer. We find that genetic ablation or therapeutic inactivation of mast cells suppresses accumulation of tumor-associated macrophages, reduces tumor cell proliferation and angiogenesis, and diminishes tumor...
Paper Details
Title
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Published Date
Jun 21, 2019
Journal
Volume
10
Issue
1
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Notes
History