Insulin Resistance Is a Risk Factor for Overall Cerebral Small Vessel Disease Burden in Old Nondiabetic Healthy Adult Population

Background and Purpose：This study aimed to investigate whether insulin resistance (IR) was associated with overall cerebral small vessel disease (CSVD) burden, independent of other clinical risk factors in old nondiabetic healthy subjects. Methods: We recruited old nondiabetic healthy subjects with no taking any medications prospectively. The overall effect of CSVD on the brain was described by validated CSVD score. The homeostasis model...