Original paper
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Volume: 24, Issue: 12, Pages: 1116 - 1123
Published: Oct 23, 2017
Abstract
Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone DNA repair by alternative nonhomologous end joining (alt-NHEJ). Here we present structure-function analyses that reveal that, in addition to the polymerase domain, Polθ-helicase activity plays a central role during double-strand break (DSB) repair. Our results show that the helicase domain promotes chromosomal translocations by alt-NHEJ in mouse embryonic...
Paper Details
Title
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Published Date
Oct 23, 2017
Volume
24
Issue
12
Pages
1116 - 1123
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Notes
History