Original paper
A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO
Abstract
Background: Hemophilia A is caused by deficiency of factor VIII (F.VIII), an essential blood-clotting cofactor. The current standard of care involves prophylactic or on-demand use of F.VIII. However, approximately 30% of severe hemophilia A patients develop inhibitory antibodies against the replacement factor VIII. Additionally, venous infusion of F.VIII is burdensome especially in pediatric patients. Hemlibra®, a humanized bispecific antibody...
Paper Details
Title
A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO
Published Date
Nov 13, 2019
Journal
Volume
134
Issue
Supplement_1
Pages
2410 - 2410
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Notes
History