S124 IDENTIFICATION OF THE DOPAMINE AND SEROTONIN TRANSPORTERS SLC6A3 AND SLC6A4 AS NOVEL SURVIVAL FACTORS IN LEUKEMIC STEM CELLS IN CHRONIC MYELOID LEUKAEMIA

Background: In chronic myeloid leukaemia (CML), BCR-ABL tyrosine kinase inhibitors (TKI) fail to eliminate leukaemia stem cells (LSC) which can serve as a reservoir to drive relapse, TKI resistance and promote disease progression. Therefore, identification of pathways/targets that promote LSC survival is essential for the development of curative therapies. Our previous transcriptomics analysis pointed to neurotransmitter pathways as being...