Original paper
S124 IDENTIFICATION OF THE DOPAMINE AND SEROTONIN TRANSPORTERS SLC6A3 AND SLC6A4 AS NOVEL SURVIVAL FACTORS IN LEUKEMIC STEM CELLS IN CHRONIC MYELOID LEUKAEMIA
Abstract
Background: In chronic myeloid leukaemia (CML), BCR-ABL tyrosine kinase inhibitors (TKI) fail to eliminate leukaemia stem cells (LSC) which can serve as a reservoir to drive relapse, TKI resistance and promote disease progression. Therefore, identification of pathways/targets that promote LSC survival is essential for the development of curative therapies. Our previous transcriptomics analysis pointed to neurotransmitter pathways as being...
Paper Details
Title
S124 IDENTIFICATION OF THE DOPAMINE AND SEROTONIN TRANSPORTERS SLC6A3 AND SLC6A4 AS NOVEL SURVIVAL FACTORS IN LEUKEMIC STEM CELLS IN CHRONIC MYELOID LEUKAEMIA
Published Date
Jun 1, 2019
Journal
Volume
3
Issue
S1
Pages
14 - 14
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