Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase
Abstract
Myoglobin (Mb) maturation involves heme incorporation as a final step. We investigated a role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and cell lines. We found the following: 1) Hsp90 directly interacts preferentially with heme-free Mb both in purified form and in cells. 2) Hsp90 drives heme insertion into apoprotein-Mb in an ATP-dependent process. 3) During differentiation of C2C12 myoblasts into...
Paper Details
Title
Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase
Published Date
Jun 6, 2019
Journal
Volume
33
Issue
9
Pages
9885 - 9896
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