Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?

Recent studies have converged on the importance of neuroinflammatory processes in nonautoimmune neurodegenerative diseases, with a special focus on microglia. Many studies have demonstrated the heterogeneity of this cell type with a diverse number of functions in the brain. One emerging finding is the vast sex differences in the transcriptional and functional properties of microglia. These differences could be mediated by both sex hormone...