Insights from the Third Dimension: Cardiac Organoids Help Identify Regenerative Pathways

In this issue of Cell Stem Cell, Mills et al. (2019) use multidimensional functional screening to identify pro-proliferative compounds in cell-cycle-arrested human cardiac organoids. Using this model, the authors identify two hit compounds that restart cardiomyocyte proliferation by synergistically activating the mevalonate pathway and cell-cycle-related...