1399-P: The Accumulative Impact of Insulin Sensitivity throughout Pregnancy on Neonatal Fatness

Published on Jun 1, 2019in Diabetes7.199
· DOI :10.2337/db19-1399-P
Rodrigo Antunes Lima , Mireille N. M. van Poppel39
Estimated H-index: 39
+ 1 AuthorsGernot Desoye47
Estimated H-index: 47
Aim: To evaluate the direct and indirect associations between insulin sensitivity during pregnancy and neonatal fatness. Methods: This is a longitudinal, secondary analysis of the DALI study which was a multicenter study conducted in nine European countries. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m2, Results: In total, 701 mother-infant pairs (51.0% boys) were included. Neonatal girls exhibited higher sum of skinfolds compared to boys (20.5 mm [±5.5] vs. 21.6 mm [±5.3]; p=0.03). HOMA at 13-20 weeks but not at 24-28 or 35-37 weeks was associated with neonatal fatness. This association was mediated through Glucose 13-20weeks -> Glucose 24-28weeks -> Glucose 35-37weeks (0.599 SD for boys and 0.467 SD for girls) and TG 13-20weeks -> TG 24-28weeks -> TG 35-37weeks (0.464 SD for boys and 0.497 SD for girls). The pathway with FFA did not mediate the association between HOMA and neonatal fatness. Conclusions: Maternal health profile in the first trimester of pregnancy plays an important role in neonatal body fatness, since insulin sensitivity was associated with neonatal fatness via increases in HOMA-Index, glucose and triglycerides throughout pregnancy. Disclosure R.A. Lima: None. M. van Poppel: None. D. Simmons: Speaker9s Bureau; Self; Sanofi-Aventis. Other Relationship; Self; Medtronic. G. Desoye: None. Funding European Community9s 7th Framework Program (FP7/2007-2013)
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