Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice

•Patients with PSC showed increased IFNγ serum concentrations and elevated frequencies of hepatic CD56bright NK cells. •Less hepatic NK cells and CD8+ T cells expressing cytotoxic effector molecules after deletion of IFNγ in Mdr2−/− mice. •Less inflammatory macrophages and more restorative macrophages after genetic deletion of IFNγ. •Genetic deletion and blockage of IFNγ in Mdr2−/− mice attenuated liver fibrosis. Background and Aims Primary...