Original paper
Neuronal Small RNAs Control Behavior Transgenerationally
Abstract
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene...
Paper Details
Title
Neuronal Small RNAs Control Behavior Transgenerationally
Published Date
Jun 1, 2019
Journal
Volume
177
Issue
7
Pages
1814 - 1826.e15
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Notes
History